Signal Transduction Reagents and Kits
Echelon Biosciences Research Labs PI(3)P DIC8 AMMONIUM SALT 1 mg
PI(3)P diC8 (Phosphatidylinositol 3-phosphate diC8) is a synthetic, purified dioctanoyl PI(3)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4. This item is non returnable
Enzo Life Sciences Salubrinal (1mg). CAS: 405060-95-9
Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC50~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (BML-CC104)). Purity: ≥98% (HPLC(UV)). Solubility: Soluble in DMSO (300 mg/ml), dioxane (0.5 mg/ml), methanol (5 mg/ml) or acetonitrile (1.5 mg/ml). Long Term Storage: -20°C.
Selleck Chemical LLC 6-Methylcoumarin S4802-25mg
6-Methylcoumarin (Toncarine) a synthetic fragrance widely used in cosmetics belongs to the class of organic compounds known as coumarins and derivatives
Echelon Biosciences Research Labs LINOLENOYL LPA 10 mg
Linolenoyl LPA, 18:3 is an LPA analog with an unsaturated acyl chain. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer. This item is non returnable
Medchemexpress LLC Syk-IN-1 | 14911150-77-6 | 99.2% | 10 MG
Syk-IN-1 is a potent Syk inhibitor, with an IC50 of 35 nM. This compound is provided as a light yellow to yellow solid and is intended for research use only.
- Potent Syk inhibitor with an IC50 of 35 nM.
- Molecular weight: 366.42.
- Molecular formula: C18H22N8O.
- Appearance: solid.
- Color: light yellow to yellow.
- In vitro solubility: DMSO (100 mg/mL).
- For research use only.
Medchemexpress LLC Malic enzyme inhibitor ME1 | 522649-59-8 | 99.7% | 351.40 g·mol⁻¹ | C20H21N3O3 | 50MG
Malic enzyme inhibitor ME1 is a small-molecule, selective inhibitor of cytosolic malic enzyme (ME1) used for biochemical and cellular research. It exhibits potent inhibition of ME1 (IC50 = 0.15 μM) and is supplied as a white to off-white solid with high purity and defined storage recommendations.
- Potent ME1 inhibition (IC50 = 0.15 μM).
- High purity suitable for biochemical assays (99.7%).
- Supplied as a solid, white to off-white.
- Highly soluble in DMSO; may require sonication and warming.
- Stable when stored under recommended conditions in powder or solution.
![CPC Scientific 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid 1MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00111436-SUBS-016.PNG-250.jpg)
CPC Scientific 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid 1MG
SEQUENCE: 4-(4-Dimethylaminophenylazo)benzoyl-Tyr-Val-Ala-Asp-Ala-Pro-Val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acidONE-LETTER SEQUENCE: 4-(4-Dimethylaminophenylazo)benzoyl-YVADAPV-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acidMOLECULAR FORMULA: C61H76N12O14S1MOLECULAR WEIGHT: 1233.39STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [161877-70-9]SYNONYMS: Caspase 1 (ICE) Substrate; dabcyl-yvadapv-edans; dabcyl-tyr-val-ala-asp-ala-pro-val-edans; ICE Substrate Ii; il-1-beta Converting Enzyme Substrate Ii; il-1b Converting Enzyme Substrate Ii; 4-(4-dimethylaminophenylazo)benzoyl-tyr-val-ala-asp-ala-pro-val-5-[(2-aminoethyl)amino]-naphthalene-1-sulfonic acid; 4-(4'-dimethylaminophenylazo)benzoyl-tyrosyl-valyl-alanyl-aspartyl-alanyl-prolyl-valyl-5((2-aminoethyl)amino)naphthalene-1-sulfonic acidRESEARCH AREA: ApoptosisREFERENCES:M.W. Pennington et al., Peptide Res., 7, 72 (1994)M. Los et al., Nature 375, 81 (1995)SKU(s): SUBS-016A, SUBS-016B
Apexbio Technology LLC Calpain and cathepsin B inhibitor, selective 88191-84-8. MFCD28137700
Calpain and cathepsin B inhibitor, selective 88191-84-8. MFCD28137700
Meso Scale Discovery Phospho-STAT3 (Tyr705) Kit, 96-well plate, 25 plates, detects STAT3 pTyr705, suitable for human, mouse, rat samples, compatible with various MSD instruments
The MESO SCALE DISCOVERY Phospho-STAT3 (Tyr705) Kit is designed as a rapid and convenient assay for the detection of STAT3 phosphorylated at tyrosine 705. The kit is suitable for research applications focused on phosphoproteins and intracellular signaling across various species, including human, mouse, and rat. Utilizing a 96-well plate format, it enables efficient processing of samples with high-throughput compatibility.
- Detects STAT3 phosphorylated at Tyr705, a crucial activation site.
- Validated for use with human, mouse, and rat samples.
- Compatible with multiple MSD instruments.
- Contains all essential reagents for accurate results.
- Includes comprehensive kit contents such as SULFO-TAG antibody and various buffers.
- Intended for research use only.
- Stored as multi-component modules.
Abcam Akt Kinase Activity Assay Kit
Akt Kinase Activity Assay Kit
The product is subject to the following: Abcam Restricted Use Statement
Enzo Life Sciences (±)-Verapamil . hydrochloride (5g). CAS: 152-11-4
Blocks slow voltage-sensitive L-type Ca2+ channels. Adrenergic antagonist. Inhibits platelet-activating factor and PMA-stimulated prostaglandin production in Kupffer cells. Induces apoptosis. In vitro resistance modifier in drug resistant human tumor cell lines. Alternative name: 5-[(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropyl-valeronitrile . HCl. Purity: ≥99% (HPLC). Appearance: White crystalline powder. Solubility: Soluble in 100% ethanol (26mg/ml), methanol or water (83mg/ml). Long Term Storage: Ambient.
Enzo Life Sciences MMP-Inhibitor profiling kit, fluorometric (1x96wells)
A QUANTIZYME Assay System Complete assay system designed to examine the specificity of inhibitors against a panel of ten matrix metalloproteinase enzymes. The assays are performed in a convenient 96-well microplate format using a sensitive fluorogenic substrate . Included are active MMP enzymes, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet. Applications: Fluorescent detection, HTS Activity assay.
Akoya Biosciences TSA Cyanine 5 Reagent Pack 50-150 Slides
TSA Cyanine 3 (Cy3) reagent pack, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. These reagents amplify by depositing extra Cy5 in the localized area of the probe or antibody.